High frequency of K-ras mutations in normal appearing lung tissues and sputum of patients with lung cancer.

doi:10.1002/ijc.2910630611

Article

High frequency of K-ras mutations in normal appearing lung tissues and sputum of patients with lung cancer.

International journal of cancer - 11 Dec 1995

Yakubovskaya M S, Spiegelman V, Luo F C, Malaev S, Salnev A, Zborovskaya I, Gasparyan A, Polotsky B, Machaladze Z, Trachtenberg A C

Abstract excerpt

To evaluate the possible use of mutant ras as a biomarker for lung cancer, we have analyzed "normal appearing" lung tissue, lung tumor, lung metastases and sputum samples from patients with non-small cell lung cancer (NSCLC). As a control, we used lung tissue and sputum samples from patients with...

Topics

Aged
Codon
Female
Humans
Lung
Lung Neoplasms
Male
Middle Aged
Mutation
Oncogene Protein p21(ras)
Sputum

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