Article
High frequency of K-ras mutations in normal appearing lung tissues and sputum of patients with lung cancer.
International journal of cancer - 11 Dec 1995
Yakubovskaya M S, Spiegelman V, Luo F C, Malaev S, Salnev A, Zborovskaya I, Gasparyan A, Polotsky B, Machaladze Z, Trachtenberg A C
Abstract excerpt
To evaluate the possible use of mutant ras as a biomarker for lung cancer, we have analyzed "normal appearing" lung tissue, lung tumor, lung metastases and sputum samples from patients with non-small cell lung cancer (NSCLC). As a control, we used lung tissue and sputum samples from patients without oncological diseases or lung disorders. Our analyses were performed with the aid of enriched PCR (EPCR), a method...
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