Article
K-ras mutation in sputum of patients with or without lung cancer.
Journal of cellular biochemistry. Supplement - 1 Jan 1996
Ronai Z, Yabubovskaya M S, Zhang E, Belitsky G A
Abstract excerpt
K-ras mutation appears in about 60% of patients with non-small-cell lung cancer (NSCLC). This frequency and its presence in normal appearing tissues point to the potential of ras oncogene mutation to serve as a good biomarker. Using enriched PCR (EPCR), which enables the detection of one mutant allele in the presence of 10,000 normal alleles, we have determined the frequency of mutant ras alleles in the sputum...
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