Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human rhinovirus type 16: mutant V1210A requires capsid-binding drug for assembly of pentamers to form virions during morphogenesis.

Journal of virology - 1 Jun 2003

Lee Wai-Ming, Wang Wensheng

Abstract excerpt

Our laboratory has previously reported isolation of human rhinovirus type 16 (HRV16) mutants which depend on WIN 52035 to grow. A rapid rise of progeny virus infectivity occurred when drug was added late in growth cycles, suggesting that the drug-dependence lesion was at the step of virus assembly (W. Wang et al., J. Virol. 72:1210-1218, 1998). Here, we report that capsid subunits, 5S protomers and 14S pentamers,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Capsid
Share to Isoxazoles
Share to Polyproteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Rhinovirus

Share to Viral Proteins

Share to Virion

Share to Virus Assembly

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 12743280
DOI: 10.1128/jvi.77.11.6235-6244.2003
PMCID: PMC154994

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human rhinovirus type 16: mutant V1210A requires capsid-binding drug for assembly of pentamers to form virions during morphogenesis.PMID 12743280Read ↗

WIN 52035-dependent human rhinovirus 16: assembly deficiency caused by mutations near the canyon surface.Semantic proximity Read ↗

Pocket factors are unlikely to play a major role in the life cycle of human rhinovirus.Semantic proximity Read ↗

Use of drug-resistance mutants to identify functional regions in picornavirus capsid proteins.Semantic proximity Read ↗

A novel benzonitrile analogue inhibits rhinovirus replication.Semantic proximity Read ↗

WIN 52035-2 inhibits both attachment and eclipse of human rhinovirus 14.Semantic proximity Read ↗

Mutations in the primer grip of human immunodeficiency virus type 1 reverse transcriptase impair proviral DNA synthesis and virion maturation.Semantic proximity Read ↗

Trans-dominant inhibition of RNA viral replication can slow growth of drug-resistant viruses.Semantic proximity Read ↗

Mutations in the E9L polymerase gene of cidofovir-resistant vaccinia virus strain WR are associated with the drug resistance phenotype.Semantic proximity Read ↗

Isolation and characterization of an arildone-resistant poliovirus 2 mutant with an altered capsid protein VP1.Semantic proximity Read ↗

Characterization and treatment of cidofovir-resistant vaccinia (WR strain) virus infections in cell culture and in mice.Semantic proximity Read ↗

Isolation and characterization of cidofovir resistant vaccinia viruses.Semantic proximity Read ↗

Evidence that enviroxime targets multiple components of the rhinovirus 14 replication complex.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.