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Article

A novel benzonitrile analogue inhibits rhinovirus replication.

The Journal of antimicrobial chemotherapy - 1 Oct 2014

Lacroix Céline, Querol-Audí Jordi, Roche Manon, Franco David, Froeyen Mathy, Guerra Pablo, Terme Thierry, Vanelle Patrice, Verdaguer Núria, Neyts Johan, Leyssen Pieter

Abstract excerpt

OBJECTIVES: To study the characteristics and the mode of action of the anti-rhinovirus compound 4-[1-hydroxy-2-(4,5-dimethoxy-2-nitrophenyl)ethyl]benzonitrile (LPCRW_0005). METHODS: The antiviral activity of LPCRW_0005 was evaluated in a cytopathic effect reduction assay against a panel of human rhinovirus (HRV) strains. To unravel its precise molecular mechanism of action, a time-of-drug-addition study,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 24948704
DOI: 10.1093/jac/dku200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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