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Article

Use of drug-resistance mutants to identify functional regions in picornavirus capsid proteins.

Archives of virology. Supplementum - 1 Jan 1994

Mosser A G, Shepard D A, Rueckert R R

Abstract excerpt

The WIN drugs and similar hydrophobic compounds that insert into the capsid of picornaviruses have been shown to block viral uncoating. In some of the human rhinoviruses they also block attachment of virus to cells. Spontaneously occurring drug-resistant mutants of human rhinovirus 14 and poliovi...

Topics

Antiviral Agents
Capsid
Drug Resistance, Microbial
Hot Temperature
Mutation
Poliovirus
Rhinovirus
Structure-Activity Relationship
Virus Replication

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 8032243
DOI: 10.1007/978-3-7091-9326-6_12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8032243-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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