Isolation and characterization of an arildone-resistant poliovirus 2 mutant with an altered capsid protein VP1.

doi:10.1016/0166-3542(88)90064-2

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Article

Isolation and characterization of an arildone-resistant poliovirus 2 mutant with an altered capsid protein VP1.

Antiviral research - 1 Jan 2000

Eggers H J, Rosenwirth B

Abstract excerpt

Arildone (4-[6-(2-chloro-4-methoxyphenoxy)hexyl] -3,5-heptanedione is a selective inhibitor of poliovirus uncoating. We have isolated an arildone-resistant poliovirus 2 variant and characterized it. In single cycle growth curve experiments the resistant virus was not influenced by 1 microgram/ml...

Topics

Animals
Cell Line
Drug Resistance, Microbial
Isoelectric Focusing
Ketones
Mutation
Neutralization Tests
Peptide Fragments
Poliovirus
Viral Proteins
Viral Structural Proteins
Virus Replication

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