Article
Evidence that enviroxime targets multiple components of the rhinovirus 14 replication complex.
Archives of virology - 1 Jan 1999
Brown-Augsburger P, Vance L M, Malcolm S K, Hsiung H, Smith D P, Heinz B A
Abstract excerpt
Enviroxime and related analogs are potent inhibitors of rhinoviruses and enteroviruses in cell culture. Previous analyses of resistant mutants implicated the viral nonstructural protein 3A(B) as the likely target of drug activity. In this study, we used site-directed mutagenesis and selection of spontaneous rhinovirus 14 mutants with several enviroxime analogs to confirm the link between domains in rhinovirus 14...
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