Mutations in the primer grip of human immunodeficiency virus type 1 reverse transcriptase impair proviral DNA synthesis and virion maturation.

doi:10.1128/JVI.72.9.7676-7680.1998

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Article

Mutations in the primer grip of human immunodeficiency virus type 1 reverse transcriptase impair proviral DNA synthesis and virion maturation.

Journal of virology - 1 Sept 1998

Yu Q, Ottmann M, Pechoux C, Le Grice S, Darlix J L

Abstract excerpt

This report describes the effects of mutating highly conserved residues in the primer grip domain of human immunodeficiency virus type 1 reverse transcriptase (RT) on virus formation and infectivity. Among a series of RT mutant viruses, three (M230A, L234D, and W239A) were found to be noninfectio...

Topics

Amino Acid Sequence
DNA, Viral
Gene Products, gag
HIV Reverse Transcriptase
HIV-1
HeLa Cells
Humans
Molecular Sequence Data
Mutation
Protein Precursors
Proviruses
Virion
Virus Assembly
gag Gene Products, Human Immunodeficiency Virus
pol Gene Products, Human Immunodeficiency Virus

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Identifiers

PMID: 9696874
DOI: 10.1128/JVI.72.9.7676-7680.1998
PMCID: PMC110040

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9696874-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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