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Article

Mutations in the primer grip of human immunodeficiency virus type 1 reverse transcriptase impair proviral DNA synthesis and virion maturation.

Journal of virology - 1 Sept 1998

Yu Q, Ottmann M, Pechoux C, Le Grice S, Darlix J L

Abstract excerpt

This report describes the effects of mutating highly conserved residues in the primer grip domain of human immunodeficiency virus type 1 reverse transcriptase (RT) on virus formation and infectivity. Among a series of RT mutant viruses, three (M230A, L234D, and W239A) were found to be noninfectious or very poorly infectious. Our data indicate that these mutations in RT caused severe defects in proviral DNA...

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Identifiers

PMID: 9696874
DOI: 10.1128/JVI.72.9.7676-7680.1998
PMCID: PMC110040

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