Article
Mutations in the E9L polymerase gene of cidofovir-resistant vaccinia virus strain WR are associated with the drug resistance phenotype.
Antimicrobial agents and chemotherapy - 1 Dec 2006
Kornbluth Richard S, Smee Donald F, Sidwell Robert W, Snarsky Victoria, Evans David H, Hostetler Karl Y
Abstract excerpt
Cidofovir (CDV) is an effective drug against viruses of the Orthopoxviridae family and is active in vitro against variola virus, the cause of smallpox. However, CDV-resistant poxviruses can be generated by repeated in vitro passage in the presence of suboptimal concentrations of CDV. To determine if mutations in the E9L polymerase gene could confer resistance to this nucleoside analog, this gene was sequenced...
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