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Article

WIN 52035-dependent human rhinovirus 16: assembly deficiency caused by mutations near the canyon surface.

Journal of virology - 1 Feb 1998

Wang W, Lee W M, Mosser A G, Rueckert R R

Abstract excerpt

Three drug-dependent mutants of human rhinovirus 16 (HRV16) were characterized by sequence analyses of spontaneous mutant isolates and were genetically reconstructed from a parental cDNA plasmid. These mutants formed plaques in the presence but not in the absence of the selecting antiviral drug, WIN 52035, which binds to the capsid of wild-type virus and inhibits its attachment to the host cell. The...

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Identifiers

PMID: 9445020
DOI: 10.1128/JVI.72.2.1210-1218.1998
PMCID: PMC124598

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