WIN 52035-2 inhibits both attachment and eclipse of human rhinovirus 14.

doi:10.1128/JVI.67.4.2245-2254.1993

Back to search

Article

WIN 52035-2 inhibits both attachment and eclipse of human rhinovirus 14.

Journal of virology - 1 Apr 1993

Shepard D A, Heinz B A, Rueckert R R

Abstract excerpt

WIN compounds inhibit attachment of human rhinovirus 14 by binding to a hydrophobic pocket within the capsid and inducing conformational changes in the canyon floor, the region that binds the cellular receptor. To study the basis of drug resistance, we isolated and characterized a family of human...

Topics

Antiviral Agents
Capsid
Capsid Proteins
Drug Resistance, Microbial
HeLa Cells
Hot Temperature
Humans
In Vitro Techniques
Isoxazoles
Mutation
RNA, Viral
Rhinovirus
Virion
Virus Replication

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.