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Article

WIN 52035-2 inhibits both attachment and eclipse of human rhinovirus 14.

Journal of virology - 1 Apr 1993

Shepard D A, Heinz B A, Rueckert R R

Abstract excerpt

WIN compounds inhibit attachment of human rhinovirus 14 by binding to a hydrophobic pocket within the capsid and inducing conformational changes in the canyon floor, the region that binds the cellular receptor. To study the basis of drug resistance, we isolated and characterized a family of human rhinovirus 14 mutants resistant to WIN 52035-2. Thermostabilization data and single-cycle growth curves provided...

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Identifiers

PMID: 8383239
DOI: 10.1128/JVI.67.4.2245-2254.1993
PMCID: PMC240355

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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