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Article

Isolation and characterization of cidofovir resistant vaccinia viruses.

Virology journal - 14 May 2008

Becker Marie N, Obraztsova Maria, Kern Earl R, Quenelle Debra C, Keith Kathy A, Prichard Mark N, Luo Ming, Moyer Richard W

Abstract excerpt

BACKGROUND: The emergence of drug resistant viruses, together with the possibility of increased virulence, is an important concern in the development of new antiviral compounds. Cidofovir (CDV) is a phosphonate nucleotide that is approved for use against cytomegalovirus retinitis and for the emergency treatment of smallpox or complications following vaccination. One mode of action for CDV has been demonstrated to...

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Identifiers

PMID: 18479513
DOI: 10.1186/1743-422X-5-58
PMCID: PMC2397383

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