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Article

Characterization and treatment of cidofovir-resistant vaccinia (WR strain) virus infections in cell culture and in mice.

Antiviral chemistry & chemotherapy - 1 Jan 2005

Smee Donald F, Wandersee Miles K, Bailey Kevin W, Hostetler Karl Y, Holy Antonin, Sidwell Robert W

Abstract excerpt

The wild-type (WT) vaccinia (WR strain) virus is highly virulent to mice by intranasal inoculation, yet death can be prevented by cidofovir treatment. A cidofovir-resistant (CDV-R) mutant of the virus was developed by 15 Vero cell culture passages in order to determine cross-resistance to other inhibitors, growth characteristics, virulence in infected mice, and suitability of the animal model for studying...

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Identifiers

PMID: 16004083
DOI: 10.1177/095632020501600306

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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