Article
A NASP (N1/N2)-related protein, Sim3, binds CENP-A and is required for its deposition at fission yeast centromeres.
Molecular cell - 28 Dec 2007
Dunleavy Elaine M, Pidoux Alison L, Monet Marie, Bonilla Carolina, Richardson William, Hamilton Georgina L, Ekwall Karl, McLaughlin Paul J, Allshire Robin C
Abstract excerpt
A defining feature of centromeres is the presence of the histone H3 variant CENP-A(Cnp1). It is not known how CENP-A(Cnp1) is specifically delivered to, and assembled into, centromeric chromatin. Through a screen for factors involved in kinetochore integrity in fission yeast, we identified Sim3. Sim3 is homologous to known histone binding proteins NASP(Human) and N1/N2(Xenopus) and aligns with Hif1(S....
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