Article
A new role for the transcriptional corepressor SIN3; regulation of centromeres.
Current biology : CB - 8 Jan 2003
Silverstein Rebecca A, Richardson William, Levin Henry, Allshire Robin, Ekwall Karl
Abstract excerpt
Centromeres play a vital role in maintaining the genomic stability of eukaryotes by coordinating the equal distribution of chromosomes to daughter cells during mitosis and meiosis. Fission yeast (S. pombe) centromeres consist of a 4-9 kb central core region and 30-100 kb of flanking inner (imr/B) and outer (otr/K) repeats. These sequences direct a laminar kinetochore structure similar to that of human...
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