Article
A mutation in CSE4, an essential gene encoding a novel chromatin-associated protein in yeast, causes chromosome nondisjunction and cell cycle arrest at mitosis.
Genes & development - 1 Mar 1995
Stoler S, Keith K C, Curnick K E, Fitzgerald-Hayes M
Abstract excerpt
The centromere, a differentiated region of the eukaryotic chromosome, mediates the segregation of sister chromatids at mitosis. In this study, a Saccharomyces cerevisiae chromosome mis-segregation mutant, cse4-1, has been isolated and shown to increase the nondisjunction frequency of a chromosome bearing a mutant centromere DNA sequence. In addition, at elevated temperatures the cse4-1 allele causes a...
Topics
- Amino Acid Sequence
- Base Sequence
- Cell Division
- Chromatin
- Chromosomal Proteins, Non-Histone
- Chromosome Mapping
- Chromosomes, Fungal
- Cloning, Molecular
- DNA-Binding Proteins
- Genes, Fungal