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Article

A mutation in CSE4, an essential gene encoding a novel chromatin-associated protein in yeast, causes chromosome nondisjunction and cell cycle arrest at mitosis.

Genes & development - 1 Mar 1995

Stoler S, Keith K C, Curnick K E, Fitzgerald-Hayes M

Abstract excerpt

The centromere, a differentiated region of the eukaryotic chromosome, mediates the segregation of sister chromatids at mitosis. In this study, a Saccharomyces cerevisiae chromosome mis-segregation mutant, cse4-1, has been isolated and shown to increase the nondisjunction frequency of a chromosome bearing a mutant centromere DNA sequence. In addition, at elevated temperatures the cse4-1 allele causes a...

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Identifiers

PMID: 7698647
DOI: 10.1101/gad.9.5.573

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A mutation in CSE4, an essential gene encoding a novel chromatin-associated protein in yeast, causes chromosome nondisjunction and cell cycle arrest at mitosis.PMID 7698647Read ↗

Analysis of primary structural determinants that distinguish the centromere-specific function of histone variant Cse4p from histone H3.Semantic proximity Read ↗

The N terminus of the centromere H3-like protein Cse4p performs an essential function distinct from that of the histone fold domain.Semantic proximity Read ↗

The histone fold domain of Cse4 is sufficient for CEN targeting and propagation of active centromeres in budding yeast.Semantic proximity Read ↗

Scm3, an essential Saccharomyces cerevisiae centromere protein required for G2/M progression and Cse4 localization.Semantic proximity Read ↗

CSE4 genetically interacts with the Saccharomyces cerevisiae centromere DNA elements CDE I and CDE II but not CDE III. Implications for the path of the centromere dna around a cse4p variant nucleosome.Semantic proximity Read ↗

The centromere-specific histone variant Cse4p (CENP-A) is essential for functional chromatin architecture at the yeast 2-microm circle partitioning locus and promotes equal plasmid segregation.Semantic proximity Read ↗

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Functional complementation of human centromere protein A (CENP-A) by Cse4p from Saccharomyces cerevisiae.Semantic proximity Read ↗

Cse4 is part of an octameric nucleosome in budding yeast.Semantic proximity Read ↗

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