Article
Loss of heterozygosity analysis of mouse pulmonary adenomas induced by coal tar.
Environmental and molecular mutagenesis - 1 Jan 2003
Benavides Fernando, Conti Claudio J, LaCava Margaret, Flores Mónica, Glasscock Edward, Sternik Gabriel, Gimenez-Conti Irma B, Johnston Dennis A, Dunsford Harold A, Goldstein Lawrence S, Rodriguez Lewis V
Abstract excerpt
Manufactured gas plant (MGP) residues, commonly known as coal tars, were generated several decades ago as a byproduct of residential and industrial gas production from the distillation of coal. Previous short-term exposure studies have shown MGP residues to be tumorigenic in mouse liver and lung. In order to gain further insight into carcinogenesis by complex mixtures of environmental chemicals containing known...
Topics
- Adenoma
- Animals
- Coal Tar
- Female
- Genotype
- Loss of Heterozygosity
- Lung Neoplasms
- Mice
- Mice, Inbred C3H
- Mice, Inbred C57BL
- Polymerase Chain Reaction