Article
Syntenic relationships between genomic profiles of fiber-induced murine and human malignant mesothelioma.
The American journal of pathology - 1 Feb 2011
Jean Didier, Thomas Emilie, Manié Elodie, Renier Annie, de Reynies Aurélien, Lecomte Céline, Andujar Pascal, Fleury-Feith Jocelyne, Galateau-Sallé Françoise, Giovannini Marco, Zucman-Rossi Jessica, Stern Marc-Henri, Jaurand Marie-Claude
Abstract excerpt
Malignant mesothelioma (MM) is an aggressive tumor with a poor prognosis mainly linked to past asbestos exposure. Murine models of MM based on fiber exposure have been developed to elucidate the mechanism of mesothelioma formation. Genomic alterations in murine MM have now been partially characterized. To gain insight into the pathophysiology of mesothelioma, 16 murine and 35 human mesotheliomas were...
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