Analysis of loss of heterozygosity in murine hepatocellular tumors.

doi:10.1002/mc.2940130309

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Article

Analysis of loss of heterozygosity in murine hepatocellular tumors.

Molecular carcinogenesis - 1 Jul 1995

Manenti G, De Gregorio L, Gariboldi M, Dragani T A, Pierotti M A

Abstract excerpt

Because allelotype analysis of tumors has been important in the identification of new tumor suppressor genes, here we studied loss of heterozygosity (LOH) in a well-defined animal experimental system. We analyzed spontaneous liver tumors from C3HHc x C57BL/6J (B6C3F1) mice and urethane-induced he...

Topics

Alleles
Animals
Chromosome Aberrations
Chromosome Disorders
Chromosome Mapping
Genetic Markers
Heterozygote
Liver Neoplasms
Liver Neoplasms, Experimental
Male
Mice
Mice, Inbred C3H
Mice, Inbred C57BL
Muridae
Polymorphism, Restriction Fragment Length
Repetitive Sequences, Nucleic Acid
Sequence Deletion

Source

Open in PubMed

Identifiers

PMID: 7619222
DOI: 10.1002/mc.2940130309

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7619222-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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