Allelic loss of distal chromosome 4 in mouse lung tumors localize a putative tumor suppressor gene to a region homologous with human chromosome 1p36.

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Article

Allelic loss of distal chromosome 4 in mouse lung tumors localize a putative tumor suppressor gene to a region homologous with human chromosome 1p36.

Oncogene - 2 Nov 1995

Herzog C R, Wang Y, You M

Abstract excerpt

Loss of heterozygosity (LOH) of distal chromosome 4 was studied to localize a putative tumor suppressor gene in mouse lung neoplasia. Previous studies have implicated this region and its homologue on human chromosome 1p36-34 as sites of potential tumor suppressor genes. One hundred adenocarcinomas and 38 adenomas of the mouse lung were examined for LOH using nine simple sequence length polymorphism markers in a...

Topics

Adenocarcinoma
Adenoma
Alleles
Animals
Base Sequence
Carcinoma
Chromosome Deletion
Chromosome Mapping
Chromosomes, Human, Pair 1
DNA Primers
Genes, Tumor Suppressor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Markers

Humans

Hybrid Cells

Lung Neoplasms

Mice

Mice, Inbred Strains

Molecular Sequence Data

Source

Open in PubMed

Identifiers

PMID: 7478609

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7478609-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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