Article
Molecular Comparison of Human and Mouse Pulmonary Adenocarcinomas
1 Jan 1998
Abstract excerpt
Mice develop lung tumors similar in their histogenesis and molecular features to peripheral adenocarcinomas in humans. The advantage of this model system is that events early in tumorigenesis can be delineated and their biological consequences tested by transgenic and knockout strategies. Both human and murine adenocarcinomas contain Kras mutations; in mice these occur within weeks following carcinogen...