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Article

Complex genetic control of lung tumorigenesis in resistant mice strains.

Cancer science - 1 Nov 2017

Dassano Alice, Pintarelli Giulia, Cotroneo Chiara E, Pettinicchio Angela, Forcati Elena, De Cecco Loris, Borrego Andrea, Colombo Francesca, Dragani Tommaso A, Manenti Giacomo

Abstract excerpt

The SM/J mouse strain is resistant to chemically-induced lung tumorigenesis despite having a haplotype, in the pulmonary adenoma susceptibility locus (Pas1) locus, that confers tumor susceptibility in other strains. To clarify this inconsistent genotype-phenotype correlation, we crossed SM/J mice with another resistant strain and conducted genome-wide linkage analysis in the (C57BL/6J × SM/J)F2 progeny exposed to...

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Identifiers

PMID: 28796413
DOI: 10.1111/cas.13349
PMCID: PMC5666032

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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