Article
Allelotype analysis of mouse lung carcinomas reveals frequent allelic losses on chromosome 4 and an association between allelic imbalances on chromosome 6 and K-ras activation.
Cancer research - 1 Dec 1994
Hegi M E, Devereux T R, Dietrich W F, Cochran C J, Lander E S, Foley J F, Maronpot R R, Anderson M W, Wiseman R W
Abstract excerpt
We generated allelotypes of 38 methylene chloride-induced lung carcinomas from female C57BL/6J x C3H/6J F1 (hereafter called B6C3F1) mice. Two or more polymorphic markers per autosome, most of them microsatellites, were examined for loss of heterozygosity. Allelic losses throughout the genome wer...
Topics
- Alleles
- Animals
- Chromosome Deletion
- Female
- Gene Expression Regulation, Neoplastic
- Genes, ras
- Lung Neoplasms
- Male
- Methylene Chloride
- Mice
- Mutation
- Transcriptional Activation