Article
Allelotype analysis of mouse lung carcinomas reveals frequent allelic losses on chromosome 4 and an association between allelic imbalances on chromosome 6 and K-ras activation.
Cancer research - 1 Dec 1994
Hegi M E, Devereux T R, Dietrich W F, Cochran C J, Lander E S, Foley J F, Maronpot R R, Anderson M W, Wiseman R W
Abstract excerpt
We generated allelotypes of 38 methylene chloride-induced lung carcinomas from female C57BL/6J x C3H/6J F1 (hereafter called B6C3F1) mice. Two or more polymorphic markers per autosome, most of them microsatellites, were examined for loss of heterozygosity. Allelic losses throughout the genome were generally infrequent except for markers on chromosome 4, which were lost in approximately one-half of the carcinomas....
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