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Article

Allelic losses in mouse skin tumors induced by gamma-irradiation of p53 heterozygotes.

Japanese journal of cancer research : Gann - 1 Sept 2002

Miyazawa Tomonori, Sato Hiroki, Hatakeyama Katsuyoshi, Kitagawa Tomoyuki, Kominami Ryo

Abstract excerpt

Skin tumors were induced by gamma-irradiation in F(1) mice between C3H/He or BALB/c and MSM carrying a p53-deficient allele. The incidence was 39.1% (34/87) in p53(KO/+) mice of the C3H/MSM genetic background and 14.3% (19/133) in those of the BALB/MSM background. Interestingly, most of the tumors (82%) lost the wild-type p53 allele and no skin tumor was found in p53(+ / +) F(1) mice. This suggests a requirement...

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Identifiers

PMID: 12359052
DOI: 10.1111/j.1349-7006.2002.tb02475.x
PMCID: PMC5927138

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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