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Article

Genomic approaches to identification of tumour-susceptibility genes using mouse models.

Current opinion in genetics & development - 1 Feb 2003

Mao Jian-Hua, Balmain Allan

Abstract excerpt

Individual susceptibility to cancer in humans is determined by complex interactions between germline genetic variation and levels of exposure to environmental carcinogens or tumour promoters. Only a small fraction of cancer susceptibility is inherited in a Mendelian manner (high-penetrance familial cancer), and most tumours result from the combined effects of many gene-gene and gene-environment interactions. The...

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PMID: 12573430
DOI: 10.1016/s0959-437x(03)00005-4

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