Article
Allelotypic and cytogenetic characterization of chemically induced mouse mammary tumors: high frequency of chromosome 4 loss of heterozygosity at advanced stages of progression.
Molecular carcinogenesis - 1 Nov 1996
Aldaz C M, Liao Q Y, Paladugu A, Rehm S, Wang H
Abstract excerpt
Loss of heterozygosity (LOH) is one of the most common genetic abnormalities in cancer. To define the role of LOH and chromosomal abnormalities at various stages of mouse mammary cancer progression, we analyzed the allelotypes and karyotypes of primary mammary tumors induced in CD2F, mice by two...
Topics
- 9,10-Dimethyl-1,2-benzanthracene
- Alleles
- Animals
- Carcinogens
- Chromosomes
- Disease Progression
- Female
- Gene Deletion
- Heterozygote
- Karyotyping
- Mammary Neoplasms, Experimental
- Medroxyprogesterone Acetate