Article
Antifolate antimalarial resistance in southeast Africa: a population-based analysis.
Lancet (London, England) - 5 Apr 2003
Roper Cally, Pearce Richard, Bredenkamp Barry, Gumede Jonathan, Drakeley Chris, Mosha Frank, Chandramohan Daniel, Sharp Brian
Abstract excerpt
BACKGROUND: Sulfadoxine-pyrimethamine was first introduced for treatment of malaria in Africa during the early 1980s for cases when chloroquine treatment failed, and has since become the first-line treatment in many countries. Resistance to sulfadoxine-pyrimethamine is now increasing, especially in southeast Africa. METHODS: We characterised genetic change in dhfr and dhps genes in the Plasmodium falciparum...
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