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Article

Origins and spread of pfdhfr mutant alleles in Plasmodium falciparum.

Acta tropica - 1 Jun 2010

Mita Toshihiro

Abstract excerpt

The emergence and spread of Plasmodium falciparum parasite resistant to sulfadoxine and pyrimethamine (SP) poses a serious public health problem. Resistance is caused by point mutations in dihydrofolate reductase (pfdhfr) and dihydropteroate synthase (pfdhps), the two key enzymes in the folate biosynthetic pathway. The use of microsatellite markers flanking pfdhfr has recently shown that the invasion of limited...

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Source

Identifiers

PMID: 19607799
DOI: 10.1016/j.actatropica.2009.07.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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