Article
A shared Asian origin of the triple-mutant dhfr allele in Plasmodium falciparum from sites across Africa.
The Journal of infectious diseases - 1 Jul 2007
Maïga Oumou, Djimdé Abdoulaye A, Hubert Veronique, Renard Emmanuelle, Aubouy Agnes, Kironde Fred, Nsimba Basile, Koram Kwadwo, Doumbo Ogobara K, Le Bras Jacques, Clain Jérôme
Abstract excerpt
BACKGROUND: Usefulness of sulfadoxine-pyrimethamine as first-line therapy for uncomplicated Plasmodium falciparum malaria and intermittent preventive treatment in pregnancy throughout sub-Saharan Africa is compromised by the spread of dhfr alleles associated with pyrimethamine resistance. A predominant haplotype associated with the N51I+C59R+S108N triple-mutant dhfr allele has been reported recently in 4 African...
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