Evolution and spread of Plasmodium falciparum mutations associated with resistance to sulfadoxine-pyrimethamine in central Africa: a cross-sectional study.

doi:10.1016/S2666-5247(23)00211-2

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Article

Evolution and spread of Plasmodium falciparum mutations associated with resistance to sulfadoxine-pyrimethamine in central Africa: a cross-sectional study.

The Lancet. Microbe - 1 Dec 2023

Guémas Emilie, Coppée Romain, Ménard Sandie, du Manoir Milena, Nsango Sandrine, Makaba Mvumbi Dieudonné, Nakoune Emmanuel, Eboumbou Moukoko Carole Else, Bouyou Akotet Marielle Karine, Mirabeau Tatfeng Youtchou, Manguin Sylvie, Malekita Yobi Doudou, Akiana Jean, Kouna Lady Charlène, Mawili Mboumba Denise Patricia, Voumbo-Matoumona Dominique Fatima, Otam Alliance-Laure, Rubbo Pierre-Alain, Lombart Jean-Pierre, Kwanai Elisabeth, Cohen Olivia, Iriart Xavier, Ayong Lawrence, Lekana-Douki Jean Bernard, Ariey Frédéric, Berry Antoine

Abstract excerpt

BACKGROUND: Efficacy of sulfadoxine-pyrimethamine, the malaria chemoprophylaxis used in pregnant women, and in children when combined with amodiaquine, is threatened by the accumulation of mutations in the Plasmodium falciparum dihydropteroate synthase (pfdhps) and dihydrofolate reductase (pfdhfr) genes. Data on the prevalence of resistant alleles in central Africa and the new pfdhps I431V mutation, particularly...

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PMID: 37865113
DOI: 10.1016/S2666-5247(23)00211-2

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