Article
Multiple origins and regional dispersal of resistant dhps in African Plasmodium falciparum malaria.
PLoS medicine - 14 Apr 2009
Pearce Richard J, Pota Hirva, Evehe Marie-Solange B, Bâ El-Hadj, Mombo-Ngoma Ghyslain, Malisa Allen L, Ord Rosalynn, Inojosa Walter, Matondo Alexandre, Diallo Diadier A, Mbacham Wilfred, van den Broek Ingrid V, Swarthout Todd D, Getachew Asefaw, Dejene Seyoum, Grobusch Martin P, Njie Fanta, Dunyo Samuel, Kweku Margaret, Owusu-Agyei Seth, Chandramohan Daniel, Bonnet Maryline, Guthmann Jean-Paul, Clarke Sian, Barnes Karen I, Streat Elizabeth, Katokele Stark T, Uusiku Petrina, Agboghoroma Chris O, Elegba Olufunmilayo Y, Cissé Badara, A-Elbasit Ishraga E, Giha Hayder A, Kachur S Patrick, Lynch Caroline, Rwakimari John B, Chanda Pascalina, Hawela Moonga, Sharp Brian, Naidoo Inbarani, Roper Cally
Abstract excerpt
BACKGROUND: Although the molecular basis of resistance to a number of common antimalarial drugs is well known, a geographic description of the emergence and dispersal of resistance mutations across Africa has not been attempted. To that end we have characterised the evolutionary origins of antifolate resistance mutations in the dihydropteroate synthase (dhps) gene and mapped their contemporary distribution....
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