Article
Different origin and dispersal of sulfadoxine-resistant Plasmodium falciparum haplotypes between Eastern Africa and Democratic Republic of Congo.
International journal of antimicrobial agents - 1 Apr 2017
Baraka Vito, Delgado-Ratto Christopher, Nag Sidsel, Ishengoma Deus S, Madebe Rashid A, Mavoko Hypolite Muhindo, Nabasumba Carolyn, Lutumba Pascal, Alifrangis Michael, Van Geertruyden Jean-Pierre
Abstract excerpt
Sulfadoxine/pyrimethamine (SP) is still used for malaria control in sub-Saharan Africa; however, widespread resistance is a major concern. This study aimed to determine the dispersal and origin of sulfadoxine resistance lineages in the Democratic Republic of the Congo compared with East African Plasmodium falciparum dihydropteroate synthetase (Pfdhps) haplotypes. The analysis involved 264 isolates collected from...
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