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Article

Limited geographical origin and global spread of sulfadoxine-resistant dhps alleles in Plasmodium falciparum populations.

The Journal of infectious diseases - 15 Dec 2011

Mita Toshihiro, Venkatesan Meera, Ohashi Jun, Culleton Richard, Takahashi Nobuyuki, Tsukahara Takahiro, Ndounga Mathieu, Dysoley Lek, Endo Hiroyoshi, Hombhanje Francis, Ferreira Marcelo U, Plowe Christopher V, Tanabe Kazuyuki

Abstract excerpt

BACKGROUND: Plasmodium falciparum malaria resistant to chloroquine and pyrimethamine originated in limited foci and migrated to Africa. It remains unresolved whether P. falciparum resistance to sulfadoxine, which is conferred by mutations in dihydropteroate synthase (DHPS), evolved following a similar pattern. METHODS: The dhps locus of 893 P. falciparum isolates from 12 countries in Asia, the Pacific Islands,...

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Source

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Identifiers

PMID: 22021623
DOI: 10.1093/infdis/jir664
PMCID: PMC3209816

Genes

DHPS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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