Regional Patterns and Temporal Trends of Pfdhfr and Pfdhps Markers of Antifolate Resistance in Plasmodium falciparum in East and West Africa, 2010-2025: A Systematic Review.

Abstract excerpt

Sulfadoxine-pyrimethamine (SP) remains central to malaria chemoprevention through intermittent preventive treatment in pregnancy, intermittent preventive treatment in infancy, and seasonal malaria chemoprevention, despite widespread resistance in Plasmodium falciparum. This systematic review compared regional patterns and temporal trends of Pfdhfr and Pfdhps mutations and haplotypes associated with SP resistance...

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