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Article

Independent lineages of highly sulfadoxine-resistant Plasmodium falciparum haplotypes, eastern Africa.

Emerging infectious diseases - 1 Jul 2014

Taylor Steve M, Antonia Alejandro L, Harrington Whitney E, Goheen Morgan M, Mwapasa Victor, Chaluluka Ebbie, Fried Michal, Kabyemela Edward, Madanitsa Mwayi, Khairallah Carole, Kalilani-Phiri Linda, Tshefu Antoinette K, Rogerson Stephen J, Ter Kuile Feiko O, Duffy Patrick E, Meshnick Steven R

Abstract excerpt

Sulfadoxine-resistant Plasmodium falciparum undermines malaria prevention with sulfadoxine/pyrimethamine. Parasites with a highly resistant mutant dihydropteroate synthase (dhps) haplotype have recently emerged in eastern Africa; they negated preventive benefits of sulfadoxine/pyrimethamine, and might exacerbate placental malaria. We explored emerging lineages of dhps mutant haplotypes in Malawi, the Democratic...

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Identifiers

PMID: 24960247
DOI: 10.3201/eid2007.131720
PMCID: PMC4073871

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