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Article

Hitchhiking and selective sweeps of Plasmodium falciparum sulfadoxine and pyrimethamine resistance alleles in a population from central Africa.

Antimicrobial agents and chemotherapy - 1 Nov 2008

McCollum Andrea M, Basco Leonardo K, Tahar Rachida, Udhayakumar Venkatachalam, Escalante Ananias A

Abstract excerpt

Sulfadoxine-pyrimethamine (SP) resistance in Plasmodium falciparum is encoded by a number of mutations in the dihydrofolate reductase (dhfr) and dihydropteroate synthetase (dhps) genes. Here, we have characterized point mutations in dhfr and dhps and microsatellite loci around dhfr on chromosome 4 and dhps on chromosome 8 as well as neutral markers on chromosomes 2 and 3 in 332 samples from Yaoundé, Cameroon. The...

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Identifiers

PMID: 18765692
DOI: 10.1128/AAC.00623-08
PMCID: PMC2573158

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Source receipt: pubmed, retrieved 7 Sept 2026.

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