Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A model of repression: CTD analogs and PIE-1 inhibit transcriptional elongation by P-TEFb.

Genes & development - 15 Mar 2003

Zhang Fan, Barboric Matjaz, Blackwell T Keith, Peterlin B Matija

Abstract excerpt

The positive transcription elongation factor b (P-TEFb) contains cyclin T1 (CycT1) and cyclin-dependent kinase 9 (Cdk9). For activating the expression of eukaryotic genes, the histidine-rich sequence in CycT1 binds the heptapeptide repeats in the C-terminal domain (CTD) of RNA polymerase II (RNAPII), whereupon Cdk9 phosphorylates the CTD. We found that alanine-substituted heptapeptide repeats that cannot be...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alanine
Share to Binding, Competitive
Share to Cyclin-Dependent Kinases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glutamic Acid

Share to Histidine

Share to Ribonucleases

Share to RNA Polymerase II

Share to Serine

Source

Open in PubMed Open full text

Identifiers

PMID: 12651893
DOI: 10.1101/gad.1068203
PMCID: PMC196018

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A model of repression: CTD analogs and PIE-1 inhibit transcriptional elongation by P-TEFb.PMID 12651893Read ↗

Transcriptional repression by the Caenorhabditis elegans germ-line protein PIE-1.Semantic proximity Read ↗

P-TEFb containing cyclin K and Cdk9 can activate transcription via RNA.Semantic proximity Read ↗

CDK-9/cyclin T (P-TEFb) is required in two postinitiation pathways for transcription in the C. elegans embryo.Semantic proximity Read ↗

Tyrosine phosphorylation of RNA polymerase II CTD is associated with antisense promoter transcription and active enhancers in mammalian cells.Semantic proximity Read ↗

Dominant negative mutant cyclin T1 proteins inhibit HIV transcription by specifically degrading Tat.Semantic proximity Read ↗

Dominant negative mutant cyclin T1 proteins that inhibit HIV transcription by forming a kinase inactive complex with Tat.Semantic proximity Read ↗

Structure of the Cyclin T binding domain of Hexim1 and molecular basis for its recognition of P-TEFb.Semantic proximity Read ↗

Interactions between fission yeast Cdk9, its cyclin partner Pch1, and mRNA capping enzyme Pct1 suggest an elongation checkpoint for mRNA quality control.Semantic proximity Read ↗

The RNAPII-CTD Maintains Genome Integrity through Inhibition of Retrotransposon Gene Expression and Transposition.Semantic proximity Read ↗

A single helix repression domain is functional across eukaryotesSemantic proximity Read ↗

New eukaryotic transcriptional repressors.Semantic proximity Read ↗

TFIIH and P-TEFb coordinate transcription with capping enzyme recruitment at specific genes in fission yeast.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.