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Article

P-TEFb containing cyclin K and Cdk9 can activate transcription via RNA.

The Journal of biological chemistry - 10 May 2002

Lin Xin, Taube Ran, Fujinaga Koh, Peterlin B Matija

Abstract excerpt

Different positive transcription elongation factor b (P-TEFb) complexes isolated from mammalian cells contain a common catalytic subunit (Cdk9) and the unique regulatory cyclins CycT1, CycT2a, CycT2b, or CycK. The role of CycK as a transcriptional cyclin was demonstrated in this study. First, CycK activated transcription when tethered heterologously to RNA, which required the kinase activity of Cdk9. Although...

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Identifiers

PMID: 11884399
DOI: 10.1074/jbc.M200117200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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