Article
Transcriptional repression by the Caenorhabditis elegans germ-line protein PIE-1.
Genes & development - 15 Jan 1999
Batchelder C, Dunn M A, Choy B, Suh Y, Cassie C, Shim E Y, Shin T H, Mello C, Seydoux G, Blackwell T K
Abstract excerpt
In the early Caenorhabditis elegans embryo, maternally expressed PIE-1 protein is required in germ-line blastomeres to inhibit somatic differentiation, maintain an absence of mRNA transcription, and block phosphorylation of the RNA polymerase II large subunit (Pol II) carboxy-terminal domain (CTD...
Topics
- Amino Acid Sequence
- Animals
- Animals, Genetically Modified
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Cell Differentiation
- Genes, Reporter
- Germ Cells
- HeLa Cells
- Helminth Proteins
- Humans
- Molecular Sequence Data
- Mutation
- Nuclear Proteins