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Article

Tyrosine phosphorylation of RNA polymerase II CTD is associated with antisense promoter transcription and active enhancers in mammalian cells.

eLife - 9 May 2014

Descostes Nicolas, Heidemann Martin, Spinelli Lionel, Schüller Roland, Maqbool Muhammad Ahmad, Fenouil Romain, Koch Frederic, Innocenti Charlène, Gut Marta, Gut Ivo, Eick Dirk, Andrau Jean-Christophe

Abstract excerpt

In mammals, the carboxy-terminal domain (CTD) of RNA polymerase (Pol) II consists of 52 conserved heptapeptide repeats containing the consensus sequence Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7. Post-translational modifications of the CTD coordinate the transcription cycle and various steps of mRNA maturation. Here we describe Tyr1 phosphorylation (Tyr1P) as a hallmark of promoter (5' associated) Pol II in mammalian...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 24842994
DOI: 10.7554/eLife.02105
PMCID: PMC4042876

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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