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Article

Dominant negative mutant cyclin T1 proteins inhibit HIV transcription by specifically degrading Tat.

Retrovirology - 11 Jul 2008

Jadlowsky Julie K, Nojima Masanori, Schulte Antje, Geyer Matthias, Okamoto Takashi, Fujinaga Koh

Abstract excerpt

BACKGROUND: The positive transcription elongation factor b (P-TEFb) is an essential cellular co-factor for the transcription of the human immunodeficiency virus type 1 (HIV-1). The cyclin T1 (CycT1) subunit of P-TEFb associates with a viral protein, Tat, at the transactivation response element (TAR). This represents a critical and necessary step for the stimulation of transcriptional elongation. Therefore, CycT1...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to tat Gene Products, Human Immunodeficiency Virus

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Identifiers

PMID: 18620576
DOI: 10.1186/1742-4690-5-63
PMCID: PMC2492875

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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