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Article

TFIIH and P-TEFb coordinate transcription with capping enzyme recruitment at specific genes in fission yeast.

Molecular cell - 27 Mar 2009

Viladevall Laia, St Amour Courtney V, Rosebrock Adam, Schneider Susanne, Zhang Chao, Allen Jasmina J, Shokat Kevan M, Schwer Beate, Leatherwood Janet K, Fisher Robert P

Abstract excerpt

Cyclin-dependent kinases (CDKs) are subunits of transcription factor (TF) IIH and positive transcription elongation factor b (P-TEFb). To define their functions, we mutated the TFIIH-associated kinase Mcs6 and P-TEFb homologs Cdk9 and Lsk1 of fission yeast, making them sensitive to inhibition by bulky purine analogs. Selective inhibition of Mcs6 or Cdk9 blocks cell division, alters RNA polymerase (Pol) II...

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Share to Chromosomal Proteins, Non-Histone
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Methyltransferases

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Source

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Identifiers

PMID: 19328067
DOI: 10.1016/j.molcel.2009.01.029
PMCID: PMC2693121

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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TFIIH and P-TEFb coordinate transcription with capping enzyme recruitment at specific genes in fission yeast.PMID 19328067Read ↗

Cyclin-dependent kinase 9 (Cdk9) of fission yeast is activated by the CDK-activating kinase Csk1, overlaps functionally with the TFIIH-associated kinase Mcs6, and associates with the mRNA cap methyltransferase Pcm1 in vivo.Semantic proximity Read ↗

Separate domains of fission yeast Cdk9 (P-TEFb) are required for capping enzyme recruitment and primed (Ser7-phosphorylated) Rpb1 carboxyl-terminal domain substrate recognition.Semantic proximity Read ↗

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