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Article

Dominant negative mutant cyclin T1 proteins that inhibit HIV transcription by forming a kinase inactive complex with Tat.

The Journal of general virology - 1 Nov 2008

Jadlowsky Julie K, Nojima Masanori, Okamoto Takashi, Fujinaga Koh

Abstract excerpt

Transcription of the human immunodeficiency virus type 1 (HIV) requires the interaction of the cyclin T1 (CycT1) subunit of a host cellular factor, the positive transcription elongation factor b (P-TEFb), with the viral Tat protein, at the transactivation response element (TAR) of nascent transcripts. Because of this virus-specific interaction, CycT1 may potentially serve as a target for the development of...

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Share to Cyclins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Conformation

Share to Protein Subunits

Share to tat Gene Products, Human Immunodeficiency Virus

Share to Transcription, Genetic

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Source

Identifiers

PMID: 18931076
DOI: 10.1099/vir.0.2008/002857-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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