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Article

CDK-9/cyclin T (P-TEFb) is required in two postinitiation pathways for transcription in the C. elegans embryo.

Genes & development - 15 Aug 2002

Shim Eun Yong, Walker Amy K, Shi Yang, Blackwell T Keith

Abstract excerpt

The metazoan transcription elongation factor P-TEFb (CDK-9/cyclin T) is essential for HIV transcription, and is recruited by some cellular activators. P-TEFb promotes elongation in vitro by overcoming pausing that requires the SPT-4/SPT-5 complex, but considerable evidence indicates that SPT-4/SPT-5 facilitates elongation in vivo. Here we used RNA interference to investigate P-TEFb functions in vivo, in the...

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Identifiers

PMID: 12183367
DOI: 10.1101/gad.999002
PMCID: PMC186450

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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CDK-9/cyclin T (P-TEFb) is required in two postinitiation pathways for transcription in the C. elegans embryo.PMID 12183367Read ↗

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A Cdk9-PP1 kinase-phosphatase switch regulates the elongation-termination transition of RNA polymerase IISemantic proximity Read ↗

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