Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interactions between fission yeast Cdk9, its cyclin partner Pch1, and mRNA capping enzyme Pct1 suggest an elongation checkpoint for mRNA quality control.

The Journal of biological chemistry - 28 Feb 2003

Pei Yi, Schwer Beate, Shuman Stewart

Abstract excerpt

RNA polymerase II (pol II) is subject to an early elongation delay induced by negative factors Spt5/Spt4 and NELF, which is overcome by the positive factor P-TEFb (Cdk9/cyclin T), a protein kinase that phosphorylates the pol II C-terminal domain (CTD) and the transcription elongation factor Spt5. Although the rationale for this arrest and restart is unclear, recent studies suggest a connection to mRNA capping,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Baculoviridae
Share to Chromatography, Affinity

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromosomal Proteins, Non-Histone

Share to Cyclin-Dependent Kinases

Share to Cyclins

Share to Schizosaccharomyces pombe Proteins

Share to Transcriptional Elongation Factors

Share to Two-Hybrid System Techniques

Source

Identifiers

PMID: 12475973
DOI: 10.1074/jbc.M211713200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interactions between fission yeast Cdk9, its cyclin partner Pch1, and mRNA capping enzyme Pct1 suggest an elongation checkpoint for mRNA quality control.PMID 12475973Read ↗

Separable functions of the fission yeast Spt5 carboxyl-terminal domain (CTD) in capping enzyme binding and transcription elongation overlap with those of the RNA polymerase II CTD.Semantic proximity Read ↗

Interactions between fission yeast mRNA capping enzymes and elongation factor Spt5.Semantic proximity Read ↗

A Cdk9-PP1 kinase-phosphatase switch regulates the elongation-termination transition of RNA polymerase IISemantic proximity Read ↗

Cyclin-dependent kinase 9 (Cdk9) of fission yeast is activated by the CDK-activating kinase Csk1, overlaps functionally with the TFIIH-associated kinase Mcs6, and associates with the mRNA cap methyltransferase Pcm1 in vivo.Semantic proximity Read ↗

TFIIH and P-TEFb coordinate transcription with capping enzyme recruitment at specific genes in fission yeast.Semantic proximity Read ↗

A positive feedback loop links opposing functions of P-TEFb/Cdk9 and histone H2B ubiquitylation to regulate transcript elongation in fission yeast.Semantic proximity Read ↗

Separate domains of fission yeast Cdk9 (P-TEFb) are required for capping enzyme recruitment and primed (Ser7-phosphorylated) Rpb1 carboxyl-terminal domain substrate recognition.Semantic proximity Read ↗

The length, phosphorylation state, and primary structure of the RNA polymerase II carboxyl-terminal domain dictate interactions with mRNA capping enzymes.Semantic proximity Read ↗

Characterization of the Schizosaccharomyces pombe Cdk9/Pch1 protein kinase: Spt5 phosphorylation, autophosphorylation, and mutational analysis.Semantic proximity Read ↗

Histone H2B Monoubiquitylation Regulates Elongation-to-Termination Transition in RNA Polymerase II TranscriptionSemantic proximity Read ↗

Histone H2B Monoubiquitylation Regulates Elongation-to-Termination Transition in RNA Polymerase II TranscriptionSemantic proximity Read ↗

Distinct Cdk9-phosphatase switches act at the beginning and end of elongation by RNA polymerase IISemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.