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Article

Identification of E2F target genes that are rate limiting for dE2F1-dependent cell proliferation.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Nov 2012

Herr Anabel, Longworth Michelle, Ji Jun-Yuan, Korenjak Michael, Macalpine David M, Dyson Nicholas J

Abstract excerpt

BACKGROUND: Microarray studies have shown that the E2F transcription factor influences the expression of many genes but it is unclear how many of these targets are important for E2F-mediated control of cell proliferation. RESULTS: We assembled a collection of mutant alleles of 44 dE2F1-dependent genes and tested whether these could modify visible phenotypes caused by the tissue-specific depletion of dE2F1. More...

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PMID: 22972499
DOI: 10.1002/dvdy.23857
PMCID: PMC3760379

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ORC5

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