Article
Deregulated Expression of E2F Family Members Induces S-Phase Entry and Overcomes p16 <i> <sup>INK4A</sup> </i> -Mediated Growth Suppression
1 Mar 1996
Abstract excerpt
The E2F family of transcription factors regulate genes, whose products are essential for progression through the mammalian cell cycle. The transcriptional activity of the E2Fs is inhibited through the specific binding of the retinoblastoma protein, pRB, and the pRB homologs p107 and p130 to their transactivation domains. Seven members of the E2F transcription factor family have been isolated so far, and we were...