Article
Mutated VH genes and preferential VH3-21 use define new subsets of mantle cell lymphoma.
Blood - 15 May 2003
Walsh Sarah H, Thorsélius Mia, Johnson Anna, Söderberg Ola, Jerkeman Mats, Björck Erik, Eriksson Inger, Thunberg Ulf, Landgren Ola, Ehinger Mats, Löfvenberg Eva, Wallman Kristina, Enblad Gunilla, Sander Birgitta, Porwit-MacDonald Anna, Dictor Michael, Olofsson Tor, Sundström Christer, Roos Göran, Rosenquist Richard
Abstract excerpt
Mantle cell lymphoma (MCL) is believed to originate from a naive B cell. However, we recently demonstrated that a subset of MCL displayed mutated V(H) genes. We also reported restricted use of certain V(H) genes. To assess the prognostic impact of these new findings, we performed V(H) gene analysis of 110 patients, revealing that 18 (16%) patients had mutated and 92 (84%) patients had unmutated V(H) genes....
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