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Article

Is there a role for antigen selection in mantle cell lymphoma? Immunogenetic support from a series of 807 cases

27 Jul 2011

Abstract excerpt

We examined 807 productive IGHV-IGHD-IGHJ gene rearrangements from mantle cell lymphoma (MCL) cases, by far the largest series to date. The IGHV gene repertoire was remarkably biased, with IGHV3-21, IGHV4-34, IGHV1-8, and IGHV3-23 accounting for 46.3% of the cohort. Eighty-four of 807 (10.4%) cases, mainly using the IGHV3-21 and IGHV4-34 genes, were found to bear stereotyped heavy complementarity-determining...

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PMID: 21791422
DOI: 10.1182/blood-2011-03-343434

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