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Article

VH mutation status and VDJ rearrangement structure in mantle cell lymphoma: correlation with genomic aberrations, clinical characteristics, and outcome.

Blood - 15 Oct 2003

Kienle Dirk, Kröber Alexander, Katzenberger Tiemo, Ott German, Leupolt Elke, Barth Thomas F E, Möller Peter, Benner Axel, Habermann Annett, Müller-Hermelink Hans Konrad, Bentz Martin, Lichter Peter, Dōhner Hartmut, Stilgenbauer Stephan

Abstract excerpt

Immunoglobulin variable heavy chain gene (VH) mutation status and VDJ rearrangement structure were analyzed in 141 patients with mantle cell lymphoma (MCL) and correlated with biologic and clinical characteristics; 29% of the MCLs displayed mutated VH using a 98% germline homology cutoff. Striking differences occurred in the VH mutation subgroups with respect to the use of specific V genes. Rearrangements...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunoglobulin Heavy Chains

Share to Lymphoma, Mantle-Cell

Share to Recombination, Genetic

Share to Treatment Outcome

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Share to VDJ Recombinases

Source

Identifiers

PMID: 12842981
DOI: 10.1182/blood-2003-05-1383

Genes

ZAP70

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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VH mutation status and VDJ rearrangement structure in mantle cell lymphoma: correlation with genomic aberrations, clinical characteristics, and outcome.PMID 12842981Read ↗

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